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DeCS
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Descriptor English:
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Metabolic Detoxication, Phase I
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Descriptor Spanish:
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fase I de la desintoxicación metabólica
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Descriptor Portuguese:
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Desentoxicação Metabólica Fase I
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Synonyms English:
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Detoxication, Oxidative Metabolic
Detoxications, Oxidative Metabolic
Detoxification, Phase I
Detoxifications, Phase I
Metabolic Detoxication, Oxidative
Metabolic Detoxications, Oxidative
Metabolic Detoxification, Phase I
Oxidative Metabolic Detoxication
Oxidative Metabolic Detoxications
Phase I Detoxification
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Tree Number:
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G03.171.450.500
G03.787.225.450.500
G07.690.725.225.450.500
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Definition English:
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Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS. |
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See Related English:
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Drug Interactions
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History Note English:
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2006
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Allowable Qualifiers English:
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Record Number:
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51246
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Unique Identifier:
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D050216
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Occurrence in VHL:
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Similar:
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DeCS
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